Activity 4
Scalable Synthesis
Cutting-edge, on-demand synthesis of drugs and reagents for supply chain resilience
Activity leader: André Charette
Anticipated output
AI-designed drug compounds for experimental testing
Scalable, efficient synthetic routes for drugs and reagents
Platform development
Scalable, on-demand chemical synthesis
Continuous flow chemistry
Continuous flow synthesis for AI-enhanced drug/reagent synthesis
Drawbacks of batch synthesis – the classical approach
Stepwise batches for different conditions
Difficult to automate
Higher throughput requires larger reactor volume
For rapid-response to AMR pandemics, easy-to-optimize, fast, scalable, on-demand synthetic routes are needed.
Continuous flow synthesis – our approach to scalable, on-demand synthesis
Continuous adjustment of reaction conditions
Real-time monitoring of products
AI-enhanced automation
High-throughput and scalable
Continuous flow synthesis allows on-demand generation of compound libraries for rapid responses to new AMR pathogens. Scalable synthesis using this approach will offer supply chain resilience during pandemics.
Continuous flow chemistry platform