Activity 1
Phenomic profiling
High-content imaging-based identification of druggable bacterial targets and antimicrobial hits
Activity leader: Yves Brun
Anticipated output
Database of complex bacterial responses to diverse treatments
Novel hit compounds and druggable bacterial targets
Predictive AI models of drug penetration and antibiotic activity
Platform development
Phenomics: High-throughput bacterial phenotyping
Growth & microscopy screening
Growth screening
Bacterial cell painting for high-content imaging
Dyes/fluorescent protein fusions label key parts and processes in bacterial cells
High-throughput bacterial profiling of bacterial responses
Robotically integrated platform enables growth measurements and phenotypic imaging of thousands of samples
Chemical and genetic screens to identify novel drugs and drug targets
